In a recent analyze, we reported the identification and the characterization of a completely new atypical opioid receptor with exceptional detrimental regulatory properties in direction of opioid peptides.1 Our success showed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a wide-spectrum
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These final results, together with a past report showing that a little-molecule ACKR3 agonist CCX771 exhibits anxiolytic-like conduct in mice,2 aid the concept of targeting ACKR3 as a novel method to modulate the opioid system, which could open up new therapeutic avenues for opioid-related disorders.Gene expression analysis uncovered that ACKR3 is
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